Red flaky patches suddenly appear on the body and the general public thinks it is a simple skin disease and ignores them. Unexpectedly, it grows more and more and even becomes unbearable itching. The nails also have symptoms such as blotchy depressions, thickening and yellowing of the nails, etc. Don’t think it’s the fungal infection of onychomycosis, it’s actually “psoriasis” at work! Dr. Cai Yazhu, Department of Dermatology, Yadong Hospital, said that psoriasis is often mistaken for a fungal disease because of the word ringworm. In fact, psoriasis is a disease of the immune system that not only causes chronic inflammation of the skin, but also affects the nails and joints. Currently, there are five common types of psoriasis, namely psoriasis vulgaris, accounting for about 85%. The lesions are raised red and dark red plaques with clear borders, which are also combined with silvery white scales. The second is guttate psoriasis, each plaque is about 1 cm. The third type is pustular psoriasis. In addition to pustules appearing all over the body, it can also appear in a small area of the palms and soles, which has a major impact on quality of life. The fourth type is erythrodermic psoriasis, which requires 90% of the body to be affected and it is an uncommon type. The fifth type is inversion psoriasis, which often occurs in the folds (armpits, crotch, under the breasts). Since the symptoms are less obvious, the diagnosis should be made by a dermatologist. In addition to psoriasis penetrating the skin, the nails are also prone to psoriasis. Dr. Cai Yazhu explained that when the patient found that the nails began to thicken, they turned orange, dotted depressions and red spots on the meniscus, and even the nail bed and nail plate were separated and appeared in the state of fragmentation, only note that it can be psoriasis in combination with nail lesions. In addition, psoriasis patients are also prone to co-morbidities such as psoriatic arthritis, three high spikes, and cardiovascular disease. We remind the public to start treatment as soon as possible to avoid the risk of irreversible joint damage from subsequent psoriatic arthritis. Traditional treatment methods for psoriasis include light therapy, oral immunomodulatory drugs, topical ointments and the latest biologic preparations, which are specially important for the treatment of moderate to severe psoriatic lesions. Currently, health insurance has paid for biologics, which must meet the requirements of moderate to severe psoriasis lesions and have a long-lasting effect. For more than 6 months and after receiving phototherapy or 2 or more oral medications with poor results, you can request treatment. Dr. Cai Yazhu explained that the current types of biological preparations can be divided into TNF-α tumor necrosis factor inhibitors, IL12/23 inhibitors, IL-17 inhibitors and IL-23 inhibitors. Patients should discuss the appropriate treatment plan in detail with their doctor, depending on their own circumstances. With the popularization of the new crown vaccine, many people are concerned about whether the treatment should be interrupted during vaccination. Dr. Cai Yazhu recalled that psoriasis patients taking biologics can continue to be treated. However, some oral drugs must be separated, so consult the attending physician. Finally, I appeal to you, whatever treatment you use, if in doubt discuss this with your doctor and do not interrupt the treatment yourself!